Water → 5-(5-(aminomethyl)-2-chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2H-1,2,4-triazol-3 (4H)-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Water	HCID 962	—
Edukt	Potassium Hydroxide	HCID 14797	—
Edukt	N-(4-chloro-5-(1-(4-chlorophenyl)-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-2-fluorobenzyl)-2,2,2-trifluoroacetamide	HCID 136492385	—
Lösungsmittel	Tetrahydrofuran	HCID 8028	—
Produkt	5-(5-(aminomethyl)-2-chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2H-1,2,4-triazol-3 (4H)-one	HCID 136644848	55,6%

Reaktionsschritte

The title compound was prepared according to the procedure described in Intermediate-66 by using N-(4-chloro-5-(1-(4-chlorophenyl)-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-2-fluorobenzyl)-2,2,2-trifluoroacetamide (0.160 g), KOH (0.050 g), water (2 mL) and THF (10.0 mL) to afford 0.070 g of the desired product.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09439890B2
Quelldatensatz	uspto-grants-2016_09
ORD ID	ord-e5ee958621a94366a9b8c5f1153f74f6
Quellennotiz	uspto-grants-2016_09