4-Fluorobenzenesulfonyl chloride → HCID 89875926, Verbindung

HRID 594117

Reaktionsgleichung

Reaktionsgleichung von HRID 594117
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[F:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>N1C=CC=CC=1>[F:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:10][C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][N:8]=2)(=[O:20])=[O:19])=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 179858055-(Propan-2-yl)pyridin-2-amine

Produkt 1

HCID 89875926HCID 89875926, VerbindungAusbeute 66,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

5-isopropylpyridin-2-amine (300 mg, 2.20 mmol) and 4-fluorobenzene-1-sulfonyl chloride (557 mg, 2.86 mmol) were dissolved in pyridine (3 mL) and left to stand overnight. The reaction mixture was concentrated in vacuo and the crude product extracted to the organic phase of an acidic workup between ethyl acetate and 5% citric acid. The organic phase was passed through a hydrophobic frit and concentrated in vacuo to give the title compound (430 mg). LCMS (2 min, formic) Rt 0.90 min, m/z (ES+) 295 (M+H).

Aufarbeitung

  1. waitleft
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. extractionthe crude product extracted to the organic phase of an acidic workup between ethyl acetate and 5% citric acid
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cb801e81b9cb49548a2316c7451a05f4
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242972B2

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