Styrene-4-sulfonyl chloride → HCID 89876040, Verbindung

HRID 594141

Reaktionsgleichung

Reaktionsgleichung von HRID 594141
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1)=[CH2:12]>N1C=CC=CC=1>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][S:19]([C:16]2[CH:17]=[CH:18][C:13]([CH:11]=[CH2:12])=[CH:14][CH:15]=2)(=[O:21])=[O:20])=[N:8][CH:9]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 9855777Styrene-4-sulfonyl chlorideHCID 179858055-(Propan-2-yl)pyridin-2-amine

Produkt 1

HCID 89876040HCID 89876040, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 5-isopropylpyridin-2-amine (400 mg, 2.94 mmol) in pyridine (5 mL), stirred at room temperature, was added 4-vinylbenzene-1-sulfonyl chloride (760 mg, 3.75 mmol). The reaction mixture was stirred for 30 minutes then stood overnight. The solvent was evaporated in vacuo and the crude sample purified by normal phase chromatography on silica (Si) (0-50% ethyl acetate-cyclohexane gradient). The appropriate fractions were combined and evaporated in vacuo to give the title product, 670 mg, as an off-white solid. LCMS (2 min, formic) Rt 0.98 min, m/z (ES+) 303 (M+H).

Aufarbeitung

  1. waitthen stood overnight
  2. customThe solvent was evaporated in vacuo
  3. customthe crude sample purified by normal phase chromatography on silica (Si) (0-50% ethyl acetate-cyclohexane gradient)
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-01faa48f2f634de2a97d950c83df31df
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242972B2

Verknüpfte Notizen

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