[CH3:1][O:2][C:3]1[C:8]([CH:9]([NH:17]S(C(C)(C)C)=O)[CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[C:7]([O:24][CH3:25])[CH:6]=[CH:5][N:4]=1.Cl.O1CCOCC1>CO>[NH2:17][CH:9]([C:8]1[C:3]([O:2][CH3:1])=[N:4][CH:5]=[CH:6][C:7]=1[O:24][CH3:25])[CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14]A cooled (0° C.) yellow solution of methyl 5-(2,4-dimethoxypyridin-3-yl)-5-(1,1-dimethylethylsulfinamido)pentanoate (653 mg; 1.75 mmol) in MeOH (14 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.90 ml; 3.60 mmol). The resulting yellow mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 1 h. The reaction mixture was then concentrated to dryness under reduced pressure and the yellow oily residue was further dried under HV to give the chlorhydrate salt of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate as a beige solid. LC-MS (conditions B): tR=0.51 min.; [M+H]+: 269.03 g/mol.
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