Hydrochloric Acid → Ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate

HRID 594360Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594360
CC(C)(S([NH:6][CH:7]([C:16]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][C:17]=1[F:24])[CH2:8][CH:9]([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=O)C.Cl.O1CCOCC1>CCO>[NH2:6][CH:7]([C:16]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][C:17]=1[F:24])[CH2:8][CH:9]([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 69083866Ethyl 4-(1,1-dimethylethylsulfinamido)-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate

Produkt 1

HCID 69085707Ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A cooled (0° C.) solution of ethyl 4-(1,1-dimethylethylsulfinamido)-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate (1.060 g; 2.84 mmol) in EtOH (15 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (1.5 ml; 6.00 mmol). The resulting mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 30 min. The reaction mixture was then concentrated to dryness under reduced pressure and the oily residue was further dried under HV to give the chlorhydrate salt of ethyl 4-amino-4-(2-fluoro-6-methoxyphenyl)-2-methylbutanoate. LC-MS (conditions A): tR=0.50 min. and [M+H]+: 270.33 g/mol.

Aufarbeitung

  1. waitat rt for 30 min
  2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
  3. customthe oily residue was further dried under HV

Quellen und Nachweise

ORD-Eintrag
ord-b1d6795c4be54723ae0e2851c0663607
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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