2-Methylbenzo[d]thiazole-5-carbaldehyde → 6-(2,6-Dimethoxyphenyl)-1-((2-methylbenzo[d]thiazol-5-yl)methyl)piperidin-2-one

HRID 594420

Reaktionsgleichung

Reaktionsgleichung von HRID 594420
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[CH3:20][C:21]1[S:22][C:23]2[CH:29]=[CH:28][C:27]([CH:30]=O)=[CH:26][C:24]=2[N:25]=1>>[CH3:19][O:18][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([O:16][CH3:17])[C:10]=1[CH:2]1[N:1]([CH2:30][C:27]2[CH:28]=[CH:29][C:23]3[S:22][C:21]([CH3:20])=[N:25][C:24]=3[CH:26]=2)[C:6](=[O:8])[CH2:5][CH2:4][CH2:3]1

Komponenten

3

Edukt 2

HCID 23088202-Methylbenzo[d]thiazole-5-carbaldehydeHCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate

Produkt 1

HCID 690824756-(2,6-Dimethoxyphenyl)-1-((2-methylbenzo[d]thiazol-5-yl)methyl)piperidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 2-methylbenzo[d]thiazole-5-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.78 min.; [M+H]+: 397.01 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-78113812e75a41dca5b9d70acaa2b38c
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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