5-Phenylpyridine-3-carbaldehyde → 7-(2,6-Dimethoxyphenyl)-1-((5-phenylpyridin-3-yl)methyl)azepan-2-one
Reaktionsgleichung
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[C:21]1([C:27]2[CH:28]=[N:29][CH:30]=[C:31]([CH:34]=2)[CH:32]=O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:20][O:19][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:11]=1[CH:2]1[N:1]([CH2:32][C:31]2[CH:30]=[N:29][CH:28]=[C:27]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:34]=2)[C:7](=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3]1Komponenten
3
Versuchsvorschrift
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 5-phenylnicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions I): tR=1.26 min.; [M+H]+: 417.20 g/mol.
Aufarbeitung
- customPrepared
- customSubsequent purification by preparative HPLC
- customafforded the target compound