1-Phenyl-1H-pyrazole-4-carbaldehyde → 7-(2,6-dimethoxyphenyl)-1-((1-phenyl-1H-pyrazol-4-yl)methyl)azepan-2-one

HRID 594512

Reaktionsgleichung

Reaktionsgleichung von HRID 594512
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[C:21]1([N:27]2[CH:31]=[C:30]([CH:32]=O)[CH:29]=[N:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:20][O:19][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:11]=1[CH:2]1[N:1]([CH2:32][C:30]2[CH:29]=[N:28][N:27]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:31]=2)[C:7](=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3]1

Komponenten

3

Edukt 2

HCID 9520891-Phenyl-1H-pyrazole-4-carbaldehydeHCID 69082587Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate

Produkt 1

HCID 690827187-(2,6-dimethoxyphenyl)-1-((1-phenyl-1H-pyrazol-4-yl)methyl)azepan-2-one

Versuchsvorschrift

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with commercially available 1-phenyl-1H-pyrazole-4-carbaldehyde. Subsequent purification by preparative HPLC the target compound. LC-MS (conditions I): tR=1.27 min.; [M+H]+: 405.81 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC the target compound

Quellen und Nachweise

ORD-Eintrag
ord-3dde72294fd24360bb8c5291efa88a97
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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