Methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate → 1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-5-(2,6-dimethoxyphenyl)pyrrolidin-2-one

HRID 594530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594530
[NH2:1][CH:2]([C:9]1[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:10]=1[O:17][CH3:18])[CH2:3][CH2:4][C:5]([O:7]C)=O.[Cl:19][C:20]1[C:21]([O:28][CH:29]([F:31])[F:30])=[N:22][CH:23]=[C:24]([CH:27]=1)[CH:25]=O>>[Cl:19][C:20]1[CH:27]=[C:24]([CH2:25][N:1]2[CH:2]([C:9]3[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:10]=3[O:17][CH3:18])[CH2:3][CH2:4][C:5]2=[O:7])[CH:23]=[N:22][C:21]=1[O:28][CH:29]([F:31])[F:30]

Komponenten

3

Edukt 2

HCID 69082397Methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoateHCID 866956143-Pyridinecarboxaldehyde, 5-chloro-6-(difluoromethoxy)-

Produkt 1

HCID 690853311-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-5-(2,6-dimethoxyphenyl)pyrrolidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate with 5-chloro-6-(difluoromethoxy)nicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.84 min.; [M+H]+: 413.32 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-9c6330c8414e4dce84a9340b87ef03b2
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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