5-(Bromomethyl)-2-phenoxypyridine → 6-(2,6-Dimethoxyphenyl)-1-((6-phenoxypyridin-3-yl)methyl)piperidin-2-one

HRID 594610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594610
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1.Br[CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:24][CH:25]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:16]([CH2:19][C:20]2[CH:25]=[N:24][C:23]([O:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[CH:22][CH:21]=2)[C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1

Komponenten

3

Edukt 2

HCID 690824005-(Bromomethyl)-2-phenoxypyridineHCID 690825266-(2,6-Dimethoxyphenyl)piperidin-2-one

Produkt 1

HCID 690826566-(2,6-Dimethoxyphenyl)-1-((6-phenoxypyridin-3-yl)methyl)piperidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)piperidin-2-one with 5-(bromomethyl)-2-phenoxypyridine. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.84 min.; [M+H]+: 419.25 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-271bc0ae8c3240dbbd1255c8a357060f
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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