HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(Bromomethyl)-4-(trifluoromethoxy)benzene | HCID 142785 | — |
| Edukt | 5-(2,6-Dimethoxyphenyl)pyrrolidin-2-one | HCID 69080911 | — |
| Produkt | 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one | HCID 69085010 | — |
Reaktionsschritte
Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 396.00 g/mol.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09242970B2 |
| Quelldatensatz | uspto-grants-2016_01 |
| ORD ID | ord-377e750005df4e2db93d27fc07a67fc4 |
| Quellennotiz | uspto-grants-2016_01 |