Methyl iodide → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

HRID 594631Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594631
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=2)[C:14](=[O:28])[CH2:13][CH2:12]1.I[CH3:30]>>[CH3:10][O:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[CH:11]1[N:15]([CH2:16][C:17]2[CH:18]=[CH:19][C:20]([O:23][C:24]([F:26])([F:25])[F:27])=[CH:21][CH:22]=2)[C:14](=[O:28])[CH:13]([CH3:30])[CH2:12]1

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 690850105-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

Produkt 1

HCID 690801865-(2,6-Dimethoxyphenyl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 8 (GP8) by C-alkylation of 5-(2,6-dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one with commercially available iodomethane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions G): tR=1.03 min.; [M+H]+: 410.02 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-ceeb2b7f59274b1984b9688f37b234ea
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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