4-(Trifluoromethoxy)benzylamine → HCID 69085698, Verbindung

HRID 594678

Reaktionsgleichung

Reaktionsgleichung von HRID 594678
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[O:14]1[CH2:19][CH2:18][O:17][C:16]2[C:20]([CH:24]=O)=[CH:21][CH:22]=[CH:23][C:15]1=2>>[O:14]1[CH2:19][CH2:18][O:17][C:16]2[C:20]([CH:24]3[N:11]([CH2:10][C:7]4[CH:6]=[CH:5][C:4]([O:3][C:2]([F:12])([F:13])[F:1])=[CH:9][CH:8]=4)[C:15](=[O:14])[CH:16]([OH:17])[CH2:20]3)=[CH:21][CH:22]=[CH:23][C:15]1=2

Komponenten

3

Edukt 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 27950332,3-Dihydro-1,4-benzodioxine-5-carbaldehyde

Produkt 1

HCID 69085698HCID 69085698, Verbindung

Versuchsvorschrift

Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B) and 10F (GP10F) using commercially available (4-(trifluoromethoxy)phenyl)methanamine and commercially available 2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 409.94 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-e80721e70d9647bda7fe8d68bf7c834d
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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