HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(Trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(3-(trifluoromethoxy)benzyl)pyrrolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(Trifluoromethoxy)benzaldehyde | HCID 605139 | — |
| Edukt | Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate | HCID 69083532 | — |
| Produkt | 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(3-(trifluoromethoxy)benzyl)pyrrolidin-2-one | HCID 69085153 | — |
Reaktionsschritte
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.97 min.; [M+H]+: 411.84 g/mol.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09242970B2 |
| Quelldatensatz | uspto-grants-2016_01 |
| ORD ID | ord-b29566f00bca4e3fa8c8d8d76d48caf2 |
| Quellennotiz | uspto-grants-2016_01 |