3-Fluoro-4-(trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3-Fluoro-4-(trifluoromethoxy)benzaldehyde	HCID 2783358	—
Edukt	Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate	HCID 69083532	—
Produkt	5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-one	HCID 69083660	—

Reaktionsschritte

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-fluoro-4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.98 min.; [M+H]+: 429.97 g/mol.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09242970B2
Quelldatensatz	uspto-grants-2016_01
ORD ID	ord-fd19b08752704f89a2aeb0827674ba71
Quellennotiz	uspto-grants-2016_01