p-(Difluoromethoxy)benzaldehyde → 1-(4-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

HRID 594730

Reaktionsgleichung

Reaktionsgleichung von HRID 594730
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[F:21][CH:22]([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1>>[F:21][CH:22]([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:1]2[CH:2]([C:11]3[C:12]([O:19][CH3:20])=[CH:13][CH:14]=[CH:15][C:16]=3[O:17][CH3:18])[CH2:3][CH:4]([CH3:10])[C:5]2=[O:7])=[CH:26][CH:25]=1

Komponenten

3

Edukt 2

HCID 2736986p-(Difluoromethoxy)benzaldehydeHCID 69085588Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate

Produkt 1

HCID 690834491-(4-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 4-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.86 min.; [M+H]+: 391.78 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-c0a1dc422846477c96b49f7f5e41cbd3
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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