4-(2,2-Difluoroethoxy)benzaldehyde → HCID 86695663, Verbindung
Reaktionsgleichung
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[F:21][CH:22]([F:33])[CH2:23][O:24][C:25]1[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=1>>[F:21][CH:22]([F:33])[CH2:23][O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][N:1]2[CH:2]([C:11]3[C:12]([O:19][CH3:20])=[CH:13][CH:14]=[CH:15][C:16]=3[O:17][CH3:18])[CH2:3][CH:4]([CH3:10])[C:5]2=[O:7])=[CH:27][CH:26]=1Komponenten
3
Versuchsvorschrift
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 4-(2,2-difluoroethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.84 min.; [M+H]+: 406.02 g/mol.
Aufarbeitung
- customPrepared
- customSubsequent purification by preparative HPLC
- customafforded the target compound