2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221, Verbindung

HRID 595134Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 595134
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

Komponenten

5

Edukt 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

Produkt 1

HCID 44119221HCID 44119221, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Aufarbeitung

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c84c742f68274ce3b497f4e5b485c297
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09243001B2

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