Methanol → Methyl 3-nitro-4-phenoxy-5-sulfamoylbenzoate

HRID 596310Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 596310
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:20](=[O:23])(=[O:22])[NH2:21])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]([OH:9])=[O:8])([O-:3])=[O:2].OS(O)(=O)=O.[CH3:29]O>>[CH3:29][O:8][C:7](=[O:9])[C:6]1[CH:10]=[C:11]([S:20](=[O:23])(=[O:22])[NH2:21])[C:12]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1199263-(Aminosulfonyl)-5-nitro-4-phenoxybenzoic acid

Produkt 1

HCID 53854447Methyl 3-nitro-4-phenoxy-5-sulfamoylbenzoate

Versuchsvorschrift

34 g (~0.1 mol) of 3-nitro-4-phenoxy-5-sulphamylbenzoic acid are dissolved in 150 ml of methanol and are heated to the boil. 5.4 ml of concentrated H2SO4 are then added slowly dropwise and the mixture is heated at reflux temperature for 10 hours. On cooling, 3-nitro-4-phenoxy-5-sulphamylbenzoic acid methyl ester crystallises.

Aufarbeitung

  1. temperatureare heated to the boil
  2. temperaturethe mixture is heated
  3. temperatureat reflux temperature for 10 hours
  4. temperatureOn cooling
  5. custom3-nitro-4-phenoxy-5-sulphamylbenzoic acid methyl ester crystallises

Quellen und Nachweise

ORD-Eintrag
ord-1248ada3f3ac430da5e68e11ecc5a4a9
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04010273

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