HCID 12674605, Verbindung → 2-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(3,3-dipropyl-1-azetidinyl)-1-methylethyl)-4-methyl-

HRID 596464Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 596464
Cl[CH2:2][CH:3]([N:5]1[CH:9]([CH3:10])[CH2:8][N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:6]1=[O:18])[CH3:4].[CH2:19]([C:22]1([CH2:26][CH2:27][CH3:28])[CH2:25][NH:24][CH2:23]1)[CH2:20][CH3:21]>C1C=CC=CC=1>[Cl:17][C:13]1[CH:12]=[C:11]([N:7]2[CH2:8][CH:9]([CH3:10])[N:5]([CH:3]([CH3:4])[CH2:2][N:24]3[CH2:25][C:22]([CH2:26][CH2:27][CH3:28])([CH2:19][CH2:20][CH3:21])[CH2:23]3)[C:6]2=[O:18])[CH:16]=[CH:15][CH:14]=1

Komponenten

4

Edukt 2

HCID 12674605HCID 12674605, VerbindungHCID 12674606HCID 12674606, Verbindung

Produkt 1

HCID 30402912-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(3,3-dipropyl-1-azetidinyl)-1-methylethyl)-4-methyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 7 g. of 3-(2-chloro-1-methylethyl)-1-(m-chlorophenyl)-4-methyl-2-imidazolidinone and 10 g. of 3,3-dipropylazetidine in 100 ml. of anhydrous benzene is heated in a bomb at 150°-160° C. for 8 hours. The solvent is evaporated under vacuum and the residue is taken up with water, alkalinized with aqueous sodium carbonate and extracted with diethyl ether. The residue obtained by evaporation of the organic layer is purified by column chromatography through silica gel, using as the eluent chloroform containing 8% of methanol. Yield 8.6 g., b.p. 220° C./0.5 mm Hg.

Aufarbeitung

  1. additionA mixture of 7 g
  2. customThe solvent is evaporated under vacuum
  3. extractionextracted with diethyl ether
  4. customThe residue obtained by evaporation of the organic layer
  5. customis purified by column chromatography through silica gel

Quellen und Nachweise

ORD-Eintrag
ord-052635ad402b40818815f6a1da4f7caa
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04011238

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