Thionyl Chloride → p-Tetradecyloxyphenylacetylchloride

HRID 596713

Reaktionsgleichung

Reaktionsgleichung von HRID 596713
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=O)=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].S(Cl)([Cl:28])=O>C1C=CC=CC=1>[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([Cl:28])=[O:25])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 10472964p-Tetradecyloxyphenylacetic acid

Produkt 1

HCID 10021844p-Tetradecyloxyphenylacetylchloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A solution of 10.0 g. p-tetradecyloxyphenylacetic acid in 100 ml. absolute benzene is treated with 19.9 g thionylchloride and refluxed for 2.5 hours. The reaction mixture is then evaporated under vacuum (i.v.) and azeotroped several times with benzene to remove residual thionylchloride, to obtain crude p-tetradecyloxyphenylacetylchloride, which may be used in Step E, below, without further refining.

Aufarbeitung

  1. temperaturerefluxed for 2.5 hours
  2. customThe reaction mixture is then evaporated under vacuum (i.v.)
  3. customazeotroped several times with benzene
  4. customto remove residual thionylchloride

Quellen und Nachweise

ORD-Eintrag
ord-5e97ab17b6eb4490a02e2bd78e3b8f55
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04011339

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