Benzoylacetone → Methanone, (3-methyl-1,4-dioxido-2-quinoxalinyl)phenyl-

HRID 596800

Reaktionsgleichung

Reaktionsgleichung von HRID 596800
[N+:1]1([O-:10])[O:5][N:4]=[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=12.[C:11]([CH2:19][C:20](=O)[CH3:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].[Na+]>C(O)C>[C:11]([C:19]1[C:20]([CH3:21])=[N+:4]([O-:5])[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N+:1]=1[O-:10])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 7166BenzoylacetoneHCID 14798Sodium HydroxideHCID 68075Benzofuroxan

Produkt 1

HCID 178428812Methanone, (3-methyl-1,4-dioxido-2-quinoxalinyl)phenyl-Ausbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred suspension of 80 g. (0.59 mol.) of benzofurazan 1-oxide and 95 g. (0.59 mol.) of benzoylacetone in 1,000 ml. of ethanol was added 1.6 g. (0.04 mol.) of finely divided sodium hydroxide. The mixture became clear after about 30 minutes. Stirring was continued for a further 16 hours, and then the solid which had precipitated was collected by filtration. It was washed with ethanol, and dried to afford 153 g. (92% yield) of 2-benzoyl-3-methylquinoxaline 1,4-dioxide, m.p. 229°-231° C.

Aufarbeitung

  1. additionTo a stirred suspension of 80 g
  2. waitwas continued for a further 16 hours
  3. customthe solid which had precipitated
  4. filtrationwas collected by filtration
  5. washIt was washed with ethanol
  6. customdried
  7. customto afford 153 g

Quellen und Nachweise

ORD-Eintrag
ord-1ea22345cfc7476cadffd9fb63a59e86
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04012385

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