Thionyl Chloride → HCID 13243694, Verbindung

HRID 597354Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 597354
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][CH3:16])=[N:13][N:14]=[C:10]3[CH2:9]N=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:6]=2[CH:23]=1.[ClH:24].N([O-])=[O:26].[Na+].S(Cl)(Cl)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[C:12]([CH2:15][CH3:16])=[N:13][N:14]=[C:10]2[CH2:9][Cl:24])=[C:6]([C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[O:26])[CH:23]=1

Komponenten

4

Edukt 3

HCID 24386Thionyl ChlorideHCID 21416257HCID 21416257, VerbindungHCID 86602196Hydrochloride sodium nitrite

Produkt 1

HCID 13243694HCID 13243694, Verbindung

Versuchsvorschrift

According to the similar procedure as described in Example 4, the reaction product of 8-bromo-1-ethyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine and 6 N hydrochloric acid-sodium nitrite is chlorinated with thionyl chloride to give 4-[4-bromo-2-(2-pyridinecarbonyl)-phenyl]-3-chloromethyl-5-ethyl-4H-1,2,4-triazole as crystals. Recrystallization from acetone gives pale yellow prisms melting at 199° to 201° C. (decomposition).

Quellen und Nachweise

ORD-Eintrag
ord-815016d0ae2a4104b6f887e13ad3c6a7
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04013763

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