3-Pentanamine → HCID 21445076, Verbindung

HRID 597463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 597463
[CH2:1]([C:5]1[N:10]=[C:9](Cl)[C:8]([N+:12]([O-:14])=[O:13])=[C:7]([Cl:15])[N:6]=1)[CH2:2][CH2:3][CH3:4].[NH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19]>C(N(CC)CC)C>[CH2:1]([C:5]1[N:6]=[C:7]([Cl:15])[C:8]([N+:12]([O-:14])=[O:13])=[C:9]([NH:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])[N:10]=1)[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 2

HCID 120193-PentanamineHCID 12280647Pyrimidine, 2-butyl-4,6-dichloro-5-nitro-

Produkt 1

HCID 21445076HCID 21445076, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

200 ml of alcohol and 4.5 g (44 m-moles) of triethylamine are added to 11 g (44 m-moles) of 2-n-butyl-4,6-dichloro-5-nitro-pyrimidine. At -50° C, 4.0 g (44 m-moles of 3-aminopentane are added dropwise. The reaction mixture is stirred for 3 hours and then evaporated. The residue is suspended in 100 ml of water and extraction is performed with ether. The ethereal extracts are dried over MgSO4 and evaporated to yield 10.5 g of 2-n-butyl-4-chloro-5-nitro-6-(3-pentylamino)-pyrimidine (nD20 : 1.5383) as a yellow oil

Aufarbeitung

  1. customevaporated
  2. extractionextraction
  3. dry with materialThe ethereal extracts are dried over MgSO4
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c56881d8bbf0483d8bf3f8acd467bb9e
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04014677

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