Hydrochloric Acid → 4-(2-Phenyl-chroman-6-yloxy)-cyclohexanone

HRID 59773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 59773
O1[C:5]2([CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[O:18][CH:17]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:16][CH2:15]4)[CH2:7][CH2:6]2)[O:4]CC1.Cl>O1CCCC1.C(OCC)(=O)C>[C:22]1([CH:17]2[CH2:16][CH2:15][C:14]3[C:19](=[CH:20][CH:21]=[C:12]([O:11][CH:8]4[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]4)[CH:13]=3)[O:18]2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 903901236-(1,4-Dioxa-spiro[4.5]dec-8-yloxy)-2-phenyl-chroman

Produkt 1

HCID 903901554-(2-Phenyl-chroman-6-yloxy)-cyclohexanoneAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

430 mg of 6-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-2-phenyl-chroman were dissolved at room temperature in 5 ml of tetrahydrofuran. 5 ml of 10% aqueous hydrochloric acid were added and stirring at room temperature was continued for 16 h. The reaction mixture was diluted with ethyl acetate and the organic layer washed with saturated aqueous solution of sodium hydrogencarbonate. The organic layer was dried with sodium sulfate and filtered, and the volatile components removed under reduced pressure. 357 mg of the title compound were obtained as a pale yellow solid.

Aufarbeitung

  1. washthe organic layer washed with saturated aqueous solution of sodium hydrogencarbonate
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. filtrationfiltered
  4. customthe volatile components removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-95dbefce21d34803ba6c07ab62feab17
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440941B2

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