Hydrochloric Acid → 1-(2-(2-(1-Benzothiophene-4-yl)ethoxy)ethyl)-3-pyrrolidinol hydrochloride

HRID 597816

Reaktionsgleichung

Reaktionsgleichung von HRID 597816
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16]3)[C:4]=2[CH:3]=[CH:2]1.[ClH:21]>C(OCC)(=O)C>[ClH:21].[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16]3)[C:4]=2[CH:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 219900741-{2-[2-(1-Benzothiophen-4-yl)ethoxy]ethyl}-3-pyrrolidinol

Produkt 1

HCID 219901791-(2-(2-(1-Benzothiophene-4-yl)ethoxy)ethyl)-3-pyrrolidinol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

0.63 g of 1-(2-(2-(1-benzothiophene-4-yl)ethoxy)ethyl)-3-pyrrolidinol was dissolved in 5.0 ml of ethyl acetate. Thereafter, 0.80 ml of an ethyl acetate solution containing 3.25 mol/l dry hydrogen chloride was added to the obtained solution. The mixture was stirred at a room temperature for 1 hour and then at 5° C. for 1 hour. Thereafter, precipitated crystals were collected by filtration. The precipitated crystals were washed with ethyl acetate and then dried, so as to obtain 0.43 g of an achromatic crystal, 1-(2-(2-(1-benzothiophene-4-yl)ethoxy)ethyl)-3-pyrrolidinol hydrochloride.

Aufarbeitung

  1. additionwas added to the obtained solution
  2. waitat 5° C. for 1 hour
  3. customThereafter, precipitated crystals
  4. filtrationwere collected by filtration
  5. washThe precipitated crystals were washed with ethyl acetate
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-63391b804e0f4f3c9c5ff4dff8318c85
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897594B2

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