Ethanol → HCID 46914009, Verbindung

HRID 597845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 597845
[C:1]([CH2:4][CH2:5][C:6]1[C:14]2[C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][CH:7]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[CH2:21]([O:2][C:1](=[O:3])[CH2:4][CH2:5][C:6]1[C:14]2[C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][CH:7]=1)[CH3:22]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 158327213-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic acid

Produkt 1

HCID 46914009HCID 46914009, VerbindungAusbeute 99 %

Versuchsvorschrift

3-Carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole (3, 52.0 g, 0.251 mol) in ethanol (100 mL) was added with sulfuric acid (1.0 mL). The reaction mixture was heated at reflux for 12 h. The solution was concentrated under reduced pressure and the resultant solids were washed with water (200 mL×2). The solids were air-dried to give 3-(3-ethoxy-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole (4, 59.0 g, 0.251 mol) as yellow solids in >99% yield.

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 12 h
  3. concentrationThe solution was concentrated under reduced pressure
  4. washthe resultant solids were washed with water (200 mL×2)
  5. customThe solids were air-dried

Quellen und Nachweise

ORD-Eintrag
ord-c2e866c8818e4e0d91f3499cf7eebf1d
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897602B2

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