Chloride → Methyl 4-amino-3-nitrobenzoate
Reaktionsgleichung
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[Cl-].[CH3:15]O>>[CH3:15][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1Komponenten
4
Versuchsvorschrift
To a mixture of 4-amino-3-nitro-benzoic acid (10.0 g, 54.9 mmol) suspended in methanol (150 mL) was added thiony chloride (3.99 mL, 54.9 mmol). The mixture was heated to reflux overnight, then cooled to room temperature and filtered. The solid recovered by filtration was rinsed with cold methanol and dried to give 8.68 g (81%) of 4-amino-3-nitro-benzoic acid methyl ester.
Aufarbeitung
- temperatureThe mixture was heated
- temperatureto reflux overnight
- filtrationfiltered
- filtrationThe solid recovered by filtration
- washwas rinsed with cold methanol
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-672a1d09152b4116b8e1310c6d95a876
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09440956B2
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