4-(Trifluoromethyl)phenylacetonitrile → 5-(2-p-Tolyl-2H-pyrazol-3-yl)-3-(4-trifluoromethyl-phenyl)-benzo[c]isoxazole

HRID 59833Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 59833
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=3)[N:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-:3])=O.[F:22][C:23]([F:34])([F:33])[C:24]1[CH:29]=[CH:28][C:27]([CH2:30]C#N)=[CH:26][CH:25]=1>>[C:18]1([CH3:21])[CH:17]=[CH:16][C:15]([N:14]2[C:10]([C:7]3[CH:8]=[CH:9][C:4]4=[N:1][O:3][C:30]([C:27]5[CH:26]=[CH:25][C:24]([C:23]([F:22])([F:33])[F:34])=[CH:29][CH:28]=5)=[C:5]4[CH:6]=3)=[CH:11][CH:12]=[N:13]2)=[CH:20][CH:19]=1

Komponenten

3

Edukt 2

HCID 753594-(Trifluoromethyl)phenylacetonitrileHCID 900328535-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole2×

Produkt 1

HCID 730531475-(2-p-Tolyl-2H-pyrazol-3-yl)-3-(4-trifluoromethyl-phenyl)-benzo[c]isoxazole

Versuchsvorschrift

The title compound, yellow solid (41 mg, 27%), MS (ISP) m/z=420.2 [(M+H)+], mp 173° C., was prepared in accordance with the general method of example 1 from 5-(4-nitro-phenyl)-1-p-tolyl-1H-pyrazole (intermediate E) (100 mg, 353 μmol) and commercially available 2-(4-trifluoromethyl-phenyl)-acetonitrile.

Quellen und Nachweise

ORD-Eintrag
ord-54e9cd09cdeb4649857804175a5b0fa8
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440962B2

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