HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminothiazole → 4-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminothiazole | HCID 2155 | — |
| Edukt | o-(Methylthio)phenol | HCID 61261 | — |
| Edukt | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Edukt | 4-Fluoro-2-(2-methylsulfanylphenoxy)aniline | HCID 63649305 | — |
| Produkt | 1-[4-Fluoro-2-(2-methylsulfanyl-phenoxy)-phenyl]-3-thiazol-2-yl-urea | HCID 57712379 | 60% |
| Produkt | 4-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene | HCID 66999152 | 68% |
Reaktionsschritte
4-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene (1.06 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 2,5-difluoro-1-nitro-benzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 4-fluoro-2-(2-methanesulfanyl-phenoxy)-phenylamine (0.52 g, 62%) following general procedure C. 1-[4-Fluoro-2-(2-methylsulfanyl-phenoxy)-phenyl]-3-thiazol-2-yl-urea (117 mg, 60%) was prepared from 4-fluoro-2-(2-methylsulfanylphenoxy)aniline (125 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07897628B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-7a3a575f698f454e85b352a902420161 |
| Quellennotiz | uspto-grants-2011_03 |