Ammonium Chloride → 6-Bromo-4-methylpyridin-3-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

Herkunft & Nachweise