Ammonium Chloride → 6-Bromo-4-methylpyridin-3-amine

HRID 59940

Reaktionsgleichung

Reaktionsgleichung von HRID 59940
[NH4+].[Cl-].[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([N+:11]([O-])=O)=[CH:6][N:5]=1>O.[Fe]>[Br:3][C:4]1[N:5]=[CH:6][C:7]([NH2:11])=[C:8]([CH3:10])[CH:9]=1

Komponenten

5

Edukt 2

HCID 25517Ammonium ChlorideHCID 3458732-Bromo-4-methyl-5-nitropyridine

Produkt 1

HCID 199260946-Bromo-4-methylpyridin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

Aufarbeitung

  1. stirringThe mixture was stirred at 90° C. for 1 h and 15 min
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried (Na2SO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-25b06232104b4fb280ad8f917456b77e
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440929B2

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