HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 59947Erstellt: 24. Oktober 2026
Cesium carbonate → 3-Fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile
https://huagongshe.com/de/reaction/59947
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 4-Amino-3-fluorobenzonitrile | HCID 2756431 | — |
| Edukt | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Edukt | 6-Bromo-1-methyl-1H-benzimidazole | HCID 23537644 | — |
| Katalysator | palladium(II) acetate | HCID 167845 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 3-Fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile | HCID 118235342 | — |
Reaktionsschritte
A mixture containing 6-bromo-1-methyl-benzimidazole (2.38 mmol), 4-amino-3-fluoro-benzonitrile (3.57 mmol), XPhos (0.95 mmol), Cs2CO3 (7.14 mmol) and Pd(OAc)2 (0.71 mmol) in dry toluene (8 mL) was stirred at 110° C. for approximately 16 h. The mixture was diluted (EtOAc), washed (H2O), dried (Na2SO4) and concentrated to yield the desired product 3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09440929B2 |
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| Quelldatensatz | uspto-grants-2016_09 |
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| ORD ID | ord-efd2f57049f347bb9455181c6f81fbac |
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| Quellennotiz | uspto-grants-2016_09 |
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