HCID 53416493, Verbindung → HCID 67228763, Verbindung

HRID 600812

Reaktionsgleichung

Reaktionsgleichung von HRID 600812
[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[C:11]([N:18]=[C:19]=S)[CH:12]=[CH:13][CH:14]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].C(OC1CC2C(CC=1)=CC=CC=2N=C=S)C.[N:38]([CH2:41][C:42]([C:44]1[CH:49]=[CH:48][C:47]([C:50]([F:53])([F:52])[F:51])=[CH:46][C:45]=1[F:54])=[O:43])=[N+]=[N-].N(CC(C1C=CC(C(F)(F)F)=CC=1)=O)=[N+]=[N-]>>[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[C:11]([NH:18][C:19]3[O:43][C:42]([C:44]4[CH:49]=[CH:48][C:47]([C:50]([F:51])([F:52])[F:53])=[CH:46][C:45]=4[F:54])=[CH:41][N:38]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 4

HCID 53416493HCID 53416493, VerbindungHCID 866096122-Ethoxy-8-isothiocyanato-1,4-dihydronaphthaleneHCID 86609614HCID 86609614, VerbindungHCID 86609615HCID 86609615, Verbindung

Produkt 1

HCID 67228763HCID 67228763, VerbindungAusbeute 16 %

Versuchsvorschrift

The title compound was prepared using the procedure as described in Example 1H, substituting the product of Example 20F (415 mg, 1.36 mmol) for the product of Example 1F and the product of Example 22A (404 mg, 1.63 mmol) for the product of Example 1G. The crude product was purified by flash chromatography eluting with 20% to 60% EtOAc/hexanes which gave 107 mg (16%) of the title compound as a yellow solid.

Aufarbeitung

  1. customThe title compound was prepared
  2. customThe crude product was purified by flash chromatography
  3. washeluting with 20% to 60% EtOAc/hexanes which

Quellen und Nachweise

ORD-Eintrag
ord-8a3701485d6247e7843411af5deb8e45
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902236B2

Verknüpfte Notizen

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