2-Amino-5-bromobenzenesulfonamide → N-[2-(aminosulfonyl)phenyl]-4-hydroxy-1-isobutoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

HRID 601160

Reaktionsgleichung

Reaktionsgleichung von HRID 601160
[OH:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([O:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:17])[C:3]=1[C:18]([O:20]CC)=O.C(N1C2C(=CC=CN=2)C(O)=C(C(OCC)=O)C1=O)C1C=CC=CC=1.[NH2:47][C:48]1[CH:53]=[CH:52][C:51](Br)=[CH:50][C:49]=1[S:55]([NH2:58])(=[O:57])=[O:56]>>[NH2:58][S:55]([C:49]1[CH:50]=[CH:51][CH:52]=[CH:53][C:48]=1[NH:47][C:18]([C:3]1[C:4](=[O:17])[N:5]([O:12][CH2:13][CH:14]([CH3:15])[CH3:16])[C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][CH:9]=[CH:8][N:7]=2)=[O:20])(=[O:56])=[O:57]

Komponenten

4

Edukt 3

HCID 8207002-Amino-5-bromobenzenesulfonamideHCID 54729304Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylateHCID 67063850Ethyl 4-hydroxy-1-isobutoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Produkt 1

HCID 67063721N-[2-(aminosulfonyl)phenyl]-4-hydroxy-1-isobutoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Versuchsvorschrift

The title compound was prepared according to the procedure of Example 84C substituting the product of Example 158C for the product of Example 84B and substituting 2-aminosulfonamide for the product of Example 84A (0.225 g, 86%). MS (DCI) m/z 433 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-1629f0fa9137457498f312b150ff84fd
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902203B2

Verknüpfte Notizen

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