2-Amino-5-bromobenzenesulfonamide → N-[2-(aminosulfonyl)-5-chlorothien-3-yl]-1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

HRID 601169

Reaktionsgleichung

Reaktionsgleichung von HRID 601169
[NH2:1][C:2]1[CH:6]=[C:5]([Cl:7])[S:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].NC1C=CC(Br)=CC=1S(N)(=O)=O.[CH2:24]([N:31]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34]([OH:41])=[C:33]([C:42](OCC)=[O:43])[C:32]1=[O:47])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[NH2:11][S:8]([C:3]1[S:4][C:5]([Cl:7])=[CH:6][C:2]=1[NH:1][C:42]([C:33]1[C:32](=[O:47])[N:31]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:40]2[C:35]([C:34]=1[OH:41])=[CH:36][CH:37]=[CH:38][CH:39]=2)=[O:43])(=[O:9])=[O:10]

Komponenten

4

Edukt 3

HCID 8207002-Amino-5-bromobenzenesulfonamideHCID 109559343-Amino-5-chlorothiophene-2-sulfonamideHCID 54711837Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

Produkt 1

HCID 67063731N-[2-(aminosulfonyl)-5-chlorothien-3-yl]-1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Versuchsvorschrift

The title compound is prepared according to the procedure of Example 84C substituting the product of Example 174A for the product of Example 84A and substituting the product of Example 99A for the product of example Example 84B.

Quellen und Nachweise

ORD-Eintrag
ord-28bde75c0e594c23bc7208f753ae7cbe
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902203B2

Verknüpfte Notizen

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