Reaktionsgleichung
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([Cl:18])=[CH:15][N:16]=2)[C:11]([OH:19])=[C:10]([C:20](OCC)=[O:21])[C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1C2C(=CC=CN=2)C(O)=C(C(OCC)=O)C1=O)C1C=CC=CC=1.[NH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][C:52]=1[S:57]([NH2:60])(=[O:59])=[O:58].NC1C=CC(Br)=CC=1S(N)(=O)=O>>[NH2:60][S:57]([C:52]1[CH:53]=[CH:54][CH:55]=[CH:56][C:51]=1[NH:50][C:20]([C:10]1[C:9](=[O:25])[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:17]2[C:12]([C:11]=1[OH:19])=[CH:13][C:14]([Cl:18])=[CH:15][N:16]=2)=[O:21])(=[O:58])=[O:59]Komponenten
5
Edukt 4
Produkt 1
Versuchsvorschrift
The title compound was prepared according to the procedure of Example 84C substituting ethyl 1-benzyl-6-chloro-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate for the product of Example 84B and substituting 2-amino-benzenesulfonamide for the product of Example 84A. 1H NMR (300 MHz, DMSO-d6) δ ppm 5.64 (s, 2 H) 7.25 (m, 5 H) 7.44 (t, J=7.72 Hz, 1 H) 7.52 (s, 2 H) 7.67 (m, 1 H) 7.93 (m, 2 H) 8.56 (d, J=2.57 Hz, 1 H) 8.87 (d, J=2.57 Hz, 1 H) 12.34 (s, 1 H) 16.76 (s, 1 H).
Quellen und Nachweise
- ORD-Eintrag
- ord-4d9f25fe4e6e465b9b5dd6b9e46470d5
- Quelldatensatz
- uspto-grants-2011_03
- Patentnummer
- US07902203B2
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