StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Methyl 2-aminopyridine-4-carboxylate → Methyl 2-(2,5-difluorophenyl)imidazo[1,2-a]pyridine-7-carboxylate

HRID 60127
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 60127
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[F:12])=O.[NH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][N:23]=1)[C:17]([O:19][CH3:20])=[O:18]>C(O)C>[F:12][C:6]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:5]=1[C:3]1[N:13]=[C:14]2[CH:15]=[C:16]([C:17]([O:19][CH3:20])=[O:18])[CH:21]=[CH:22][N:23]2[CH:2]=1
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

4

Edukt 2

HCID 236984Methyl 2-aminopyridine-4-carboxylateHCID 27782642-Bromo-1-(2,5-difluorophenyl)ethanone2×

Produkt 1

HCID 90383269Methyl 2-(2,5-difluorophenyl)imidazo[1,2-a]pyridine-7-carboxylateAusbeute 135,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2-Bromo-1-(2,5-difluorophenyl)ethanone (1.5 g) was added to an ethanol (8.2 ml) solution of methyl 2-aminoisonicotinate (1.0 g), and the obtained mixture was then stirred in a nitrogen atmosphere at 60° C. for 18 hours. Thereafter, 2-bromo-1-(2,5-difluorophenyl)ethanone (0.77 g) was added to the reaction solution, and the obtained mixture was then stirred for 6 hours at the same temperature as described above. Thereafter, the reaction solution was concentrated under reduced pressure, and ethyl acetate (10 ml) was then added to the obtained residue. The precipitated solid was collected by filtration, and it was washed with ethyl acetate (15 ml) and heptane (6 ml) and was then dried, so as to obtain the title compound (2.5 g) in the form of a pink solid.

Aufarbeitung

  1. stirringthe obtained mixture was then stirred for 6 hours at the same temperature
  2. concentrationThereafter, the reaction solution was concentrated under reduced pressure, and ethyl acetate (10 ml)
  3. additionwas then added to the obtained residue
  4. filtrationThe precipitated solid was collected by filtration, and it
  5. washwas washed with ethyl acetate (15 ml) and heptane (6 ml)
  6. customwas then dried

Quellen und Nachweise

ORD-Eintrag
ord-1d414470be0b476fab1ac89e737035b4
Quelldatensatz
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US09440970B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion