Hydrochloric Acid → 2-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid

HRID 60142Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 60142
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([O-:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1.[Na+]>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([OH:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 117776381Sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate

Produkt 1

HCID 839653482-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acidAusbeute 40,1 %

Versuchsvorschrift

Concentrated hydrochloric acid (0.16 ml) was added to an aqueous solution (2 ml) of the sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate (530 mg) obtained in (Example 5.2) <Step 2>, and the obtained mixture was then stirred for 15 minutes. Thereafter, the precipitated solid was collected by filtration, so as to obtain the title compound (196 mg) in the form of a whitish brown solid.

Aufarbeitung

  1. customobtained in (Example 5.2) <Step 2>
  2. filtrationThereafter, the precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-7b7af2c4c64f4917a04b13dfb4b6fb49
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440970B2

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