3,4-Difluorobenzaldehyde → 3-Fluoro-4-methanesulfonylbenzaldehyde

HRID 601606Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 601606
[Na+].[CH3:2][S:3]([O-:5])=[O:4].[F:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1F)[CH:10]=[O:11]>CS(C)=O>[F:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[S:3]([CH3:2])(=[O:5])=[O:4])[CH:10]=[O:11]

Komponenten

4

Edukt 2

HCID 5880883,4-DifluorobenzaldehydeHCID 2733271Sodium methanesulfinate

Produkt 1

HCID 212517323-Fluoro-4-methanesulfonylbenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Methane sulfinic acid sodium salt (20.1 g, 200 mmol) is added to a stirred solution of 3,4-difluorobenzaldehyde (22.5 g, 158 miol) in dry DMSO (200 ml) at 75° C. After 2 hours the reaction is poured onto ice-water (200 ml). The precipitate is filtered, washed with water and dissolved in chloroform (400 ml). The organic extract is washed with water (2×200 ml), dried over MgSO4, filtered, and the solvent is removed to give the title compound as a white solid.

Aufarbeitung

  1. additionAfter 2 hours the reaction is poured onto ice-water (200 ml)
  2. filtrationThe precipitate is filtered
  3. washwashed with water
  4. dissolutiondissolved in chloroform (400 ml)
  5. extractionThe organic extract
  6. washis washed with water (2×200 ml)
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. customthe solvent is removed

Quellen und Nachweise

ORD-Eintrag
ord-07470b0e9bfa4a0396556928c51c5bc1
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902375B2

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