Chlorosulfonic acid → 2-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

HRID 601614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 601614
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=1>>[F:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14](=[O:16])[CH3:15])=[CH:11][C:12]=1[S:2]([Cl:1])(=[O:5])=[O:3]

Komponenten

3

Edukt 2

HCID 24638Chlorosulfonic acidHCID 521187(4-Fluorophenyl)acetone

Produkt 1

HCID 858617322-Fluoro-5-(2-oxo-propyl)-benzenesulfonyl chloride

Versuchsvorschrift

To a stirred flask of chlorosulphonic acid (344 g, 2.96 mol) cooled to −10° C. is added dropwise 1-(4-fluoro-phenyl)-propan-2-one (10 g, 65 mmol). The reaction mixture is left stirring at room temperature overnight and then poured carefully onto ice. The resultant solution is extracted with ethyl acetate and the organic extracts combined, dried (MgSO4) and concentrated in vacuo to yield the titled compound.

Aufarbeitung

  1. waitThe reaction mixture is left
  2. additionpoured carefully onto ice
  3. extractionThe resultant solution is extracted with ethyl acetate
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2829276b9dfd4f709ad209f0573e4351
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902375B2

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