Ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate → Ethyl 6-(3,4-difluorophenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

HRID 601906Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 601906
O=[C:2]1[C:6]2[NH:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:9][C:5]=2[CH2:4][CH2:3]1.[F:15][C:16]1[CH:17]=[C:18]([Mg]Br)[CH:19]=[CH:20][C:21]=1[F:22]>>[F:15][C:16]1[CH:17]=[C:18]([CH:2]2[C:6]3[NH:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:9][C:5]=3[CH2:4][CH2:3]2)[CH:19]=[CH:20][C:21]=1[F:22]

Komponenten

3

Edukt 2

HCID 57659859Ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylateHCID 178505835HCID 178505835, Verbindung

Produkt 1

HCID 59180205Ethyl 6-(3,4-difluorophenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

Versuchsvorschrift

The title compound was synthesized in two steps. First, ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate was reacted with (3,4-difluorophenyl)magnesium bromide according to General Procedure 3. The resulting product was converted to the title compound by hydrogenation according to General Procedure 6.

Aufarbeitung

  1. customThe title compound was synthesized in two steps

Quellen und Nachweise

ORD-Eintrag
ord-4e9b8f06af32426a8036bd56c464bf74
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902252B2

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