HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Toluene → 6-(2-Fluorophenyl)nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Toluene | HCID 1140 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Tert-butyl 6-(2-fluorophenyl)nicotinate | HCID 67267995 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 6-(2-Fluorophenyl)nicotinic acid | HCID 24729971 | 98,7% |
Reaktionsschritte
To tert-butyl 6-(2-fluorophenyl)nicotinate (479 mg, 1.75 mmol) in DCM (12 mL) at 0° C. was added TFA (2.5 mL). After stirring at rt overnight, toluene was added (10 mL) and the solvent removed to give a white solid (375 mg, 98%), 6-(2-fluorophenyl)nicotinic acid. LC/MS (M+H)=218.0 observed, 218.06 expected.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07902373B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-e8914897738a41368082a8bb2d310a98 |
| Quellennotiz | uspto-grants-2011_03 |