3-(Dimethylamino)-2,2-dimethyl-1-propanol → 4-(3-(dimethylamino)-2,2-dimethylpropoxy)-9H-diprido[2,3-b;4',3'-d]pyrrole-6-carbonitrile

HRID 60283Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 60283
Cl[C:2]1[C:10]2[C:9]3[CH:11]=[C:12]([C:15]#[N:16])[N:13]=[CH:14][C:8]=3[N:7](COCC[Si](C)(C)C)[C:6]=2[N:5]=[CH:4][CH:3]=1.[CH3:25][N:26]([CH3:33])[CH2:27][C:28]([CH3:32])([CH3:31])[CH2:29][OH:30]>>[CH3:25][N:26]([CH3:33])[CH2:27][C:28]([CH3:32])([CH3:31])[CH2:29][O:30][C:2]1[C:10]2[C:9]3[CH:11]=[C:12]([C:15]#[N:16])[N:13]=[CH:14][C:8]=3[NH:7][C:6]=2[N:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 879193-(Dimethylamino)-2,2-dimethyl-1-propanolHCID 582666684-Chloro-9-(2-trimethylsilanyl-ethoxymethyl)-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile

Produkt 1

HCID 532505534-(3-(dimethylamino)-2,2-dimethylpropoxy)-9H-diprido[2,3-b;4',3'-d]pyrrole-6-carbonitrile

Versuchsvorschrift

The title compound was prepared following a similar procedure to the previous example with 4-chloro-9-(2-trimethylsilanyl-ethoxymethyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile, using 3-(dimethylamino)-2,2-dimethylpropan-1-ol. 1H NMR (400 MHz, d6-DMSO) δ 12.78 (s, 1H), 8.99 (d, J=0.8, 1H), 8.55 (d, J=5.7, 1H), 8.39 (d, J=0.8, 1H), 7.06 (d, J=5.8, 1H), 4.12 (s, 2H), 2.41 (s, 2H), 2.24 (s, 6H), 1.10 (s, 6H). LCMS (Method E): RT=3.58 min, M+H+=324.1.

Quellen und Nachweise

ORD-Eintrag
ord-2b4dcf7002a74366ba2bfc8638d7b575
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440976B2

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