Epibromohydrin → 3-[(S)-(4-chlorophenyl)(3-hydroxyazetidin-1-yl)methyl]benzonitrile

HRID 602972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 602972
Cl.Cl[CH2:3][CH:4]([OH:23])[CH2:5][NH:6][C@@H:7]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[C:11]#[N:12].C([O-])(O)=O.[Na+].C(C1OC1)Br>C(O)(C)C>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([C@H:7]([N:6]2[CH2:5][CH:4]([OH:23])[CH2:3]2)[C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[C:11]#[N:12])=[CH:17][CH:18]=1

Komponenten

5

Edukt 3

HCID 18430EpibromohydrinHCID 516892Sodium BicarbonateHCID 670553393-[(S)-[(3-chloro-2-hydroxypropyl)amino](4-chlorophenyl)methyl]benzonitrile hydrochloride

Produkt 1

HCID 576121723-[(S)-(4-chlorophenyl)(3-hydroxyazetidin-1-yl)methyl]benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To a mixture of 20.27 g (72.6 mmole) of 3-[(S)-[(3-chloro-2-hydroxypropyl)amino](4-chlorophenyl)methyl]benzonitrile hydrochloride and 21.3 g (245 mmole) of NaHCO3 in 600 mL of isopropanol was added 14.4 mL (174 mmole) of epibromohydrin . The mixture was heated to reflux for 24 h, then was cooled and concentrated. The residue was partitioned between 750 mL portions of ether and water and the aqueous layer was washed with two 500 mL portions of ether. The combined organic extracts were washed with brine, dried over MgSO4 and concentrated. The residue was purified by flash chromatography using 10-20% ethyl acetate in hexane to afford the title compound as a clear oil; 1H-NMR(CDCl3) δ 1.6 (s, 2H, br), 5.24 (s, 1H), 7.24-7.78 (m, 8H).2.89 (m, 2H), 3.54 (m, 2H), 4.39 (s, 1H), 4.52 (m, 1H), 7.2-7.8 (m, 8H).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 24 h
  3. temperaturewas cooled
  4. concentrationconcentrated
  5. customThe residue was partitioned between 750 mL portions of ether and water
  6. washthe aqueous layer was washed with two 500 mL portions of ether
  7. washThe combined organic extracts were washed with brine
  8. dry with materialdried over MgSO4
  9. concentrationconcentrated
  10. customThe residue was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-25e24121dc76486aaea64b73662b309f
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07906652B2

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