Dichloromethane → 2-Hydroxy-5-[3-(2-methoxy-phenyl)-1-(toluene-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid methyl ester

HRID 603023Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 603023
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[C:17]2[C:12](=[N:13][CH:14]=[C:15](B3OC(C)(C)C(C)(C)O3)[CH:16]=2)[N:11]([S:27]([C:30]2[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=2)(=[O:29])=[O:28])[CH:10]=1.Br[C:38]1[CH:47]=[C:42]([C:43]([O:45][CH3:46])=[O:44])[C:41]([OH:48])=[CH:40][CH:39]=1.ClCCl>C([O-])(O)=O.[Na+].C(#N)C.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[CH3:46][O:45][C:43](=[O:44])[C:42]1[CH:47]=[C:38]([C:15]2[CH:16]=[C:17]3[C:9]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=4[O:2][CH3:1])=[CH:10][N:11]([S:27]([C:30]4[C:31]([CH3:32])=[CH:36][CH:33]=[CH:34][CH:35]=4)(=[O:29])=[O:28])[C:12]3=[N:13][CH:14]=2)[CH:39]=[CH:40][C:41]=1[OH:48]

Komponenten

7

Edukt 3

HCID 6344DichloromethaneHCID 77683Methyl 5-bromosalicylateHCID 160390673-(2-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 670612012-Hydroxy-5-[3-(2-methoxy-phenyl)-1-(toluene-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid methyl esterAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)KatalysatorHCID 6342AcetonitrileLösungsmittelHCID 516892Sodium BicarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of 3-(2-methoxy-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (502 mg, 1.00 mmol) in 1.5 mL saturated aqueous NaHCO3 and 5.0 mL acetonitrile was added methyl 5-bromosalicylate (253 mg, 1.10 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II), complex with dichloromethane (1.1) (41 mg, 0.05 mmol) in a microwave vial. The vial was capped, flushed with N2, evacuated under vacuum, and subsequently heated in a microwave at 90° C. for 300 seconds. The material was diluted with ethyl acetate and the organic layer was washed with saturated NaHCO3 (aq) and brine then dried over Na2SO4. The material was filtered, then adsorbed onto silica gel and purified by flash chromatography with a gradient of ethyl acetate and hexane, affording the title compound as a hydroscopic white solid (480 mg, 91% yield). 1H NMR (500 MHz, CD3OD) δ8.55 (d, J=2.0 Hz, 1H), 8.06 (m, 4H), 7.96 (s, 1H), 7.77 (dd. J=2.5, 6.0 Hz, 1H), 7.52 (dd, J=2.0, 6.0 Hz, 1H), 7.40 (m, 3H), 7.16 (d, J=8.5 Hz, 1H), 7.08 (m, 2H), 3.98 (s, 3H), 3.87 (s, 3H), 2.39 (s, 3H). MS: m/z 529.1 (M+H+).

Aufarbeitung

  1. customThe vial was capped
  2. customflushed with N2
  3. customevacuated under vacuum
  4. additionThe material was diluted with ethyl acetate
  5. washthe organic layer was washed with saturated NaHCO3 (aq) and brine
  6. dry with materialthen dried over Na2SO4
  7. filtrationThe material was filtered
  8. custompurified by flash chromatography with a gradient of ethyl acetate and hexane

Quellen und Nachweise

ORD-Eintrag
ord-a0326f505e434bfab4262bbe8ca67c7a
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07906648B2

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