Pyridine → HCID 57656788, Verbindung

HRID 603168

Reaktionsgleichung

Reaktionsgleichung von HRID 603168
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[C:4]([Cl:12])[CH:3]=1.N1C=CC=CC=1.[Cl:19][C:20]([Cl:25])([Cl:24])[C:21](Cl)=[O:22]>ClCCl>[Cl:19][C:20]([Cl:25])([Cl:24])[C:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[C:4]([Cl:12])[CH:3]=1)=[O:22]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 6420Trichloroacetyl chlorideHCID 679623-Chloro-4-(trifluoromethyl)aniline

Produkt 1

HCID 57656788HCID 57656788, VerbindungAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 4-amino-2-chlorobenzotrifluoride (300 mg) and pyridine (243 mg) in dichloromethane (10 mL) was added a solution of trichloroacetyl chloride (279 mg) in dichloromethane (5 mL) dropwise. The solution was stirred for 2 hrs and then concentrated at reduced pressure. The residue was purified by silica gel chromatography eluting with 0-10% ethyl acetate in hexane to give the title compound as a white solid (360 mg, 69%).

Aufarbeitung

  1. concentrationconcentrated at reduced pressure
  2. customThe residue was purified by silica gel chromatography
  3. washeluting with 0-10% ethyl acetate in hexane

Quellen und Nachweise

ORD-Eintrag
ord-ada302043cf441feab5994ff6e306249
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07906645B2

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