HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sulfuric acid magnesium salt (1:1) → 1-Benzyl 4-tert-butyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)methyl]piperazine-1,4-dicarboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | N-(3,4-Dichlorophenyl)piperazine-1-carboxamide | HCID 16775732 | — |
| Edukt | 4-Boc-1-Cbz-piperazine-2-carbaldehyde | HCID 59671527 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 1-Benzyl 4-tert-butyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)methyl]piperazine-1,4-dicarboxylate | HCID 57656842 | — |
Reaktionsschritte
To 1-benzyl 4-tert-butyl 2-formylpiperazine-1,4-dicarboxylate (227 mg) in THF (20 ml) were added N-(3,4-dichlorophenyl)piperazine-1-carboxamide (179 mg), DIPEA (319 ul) DMF (1.6 ml) and MgSO4 (30 mg) the mixture stirred at room temperature for 30 minutes, sodium triacetoxyborohydride (277 mg) added and stirring continued for 16 hours at room temperature. Saturated aqueous sodium bicarbonate and ethyl acetate were added. The organic phase was dried (MgSO4) and evaporated to give the title compound as a semi-solid gum (331 mg, 84%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07906645B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-a7456215a8404e3184a2b6ecf57f4599 |
| Quellennotiz | uspto-grants-2011_03 |