2-(tert-Butylamino)ethanol → 1-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol

HRID 603260

Reaktionsgleichung

Reaktionsgleichung von HRID 603260
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:12][O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:13]([NH:17][CH2:18][CH2:19][OH:20])([CH3:16])([CH3:15])[CH3:14]>C(O)C>[CH2:1]([O:8][CH2:9][CH:10]([OH:11])[CH2:12][N:17]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:18][CH2:19][OH:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 783612-(tert-Butylamino)ethanolHCID 94247Benzyl glycidyl ether

Produkt 1

HCID 576568621-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-olAusbeute 83,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-[(benzyloxy)methyl]oxirane (350 mg) and 2-(tert-butylamino)ethanol (500 mg) in ethanol (20 mL) was heated to reflux temperature and left at this temperature overnight. The solution was concentrated at reduced pressure. The residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane. This gave the title compound as a colourless oil (501 mg)

Aufarbeitung

  1. temperatureto reflux temperature
  2. concentrationThe solution was concentrated at reduced pressure
  3. filtrationThe residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-006fedb16250481cbc8dc74c7ccb5e7b
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07906645B2

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