Chloroacetyl chloride → HCID 57952152, Verbindung

HRID 603343

Reaktionsgleichung

Reaktionsgleichung von HRID 603343
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1.[Cl:17][CH2:18][C:19](Cl)=[O:20]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[N:9]([C:19](=[O:20])[CH2:18][Cl:17])[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 6577Chloroacetyl chlorideHCID 57952145N-(2'-chloro-6'-methylphenyl)-4-methylaniline

Produkt 1

HCID 57952152HCID 57952152, VerbindungAusbeute 77,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

The solution of N-(2′-chloro-6′-methylphenyl)-4-methylaniline (1.4 g) in 2.21 g chloroacetylchloride is heated to 90° C. for 4 h. The mixture is diluted with toluene (25 ml), cooled to room temperature and washed with aqu. sodium carbonate. The organic phase is dried, evaporated and the residue is subjected to flash chromatography [57 g silica, toluene and toluene/ethylacetate (98:2)] to afford 1.45 g of N-(2′-Chloro-6′-methylphenyl)-N-chloroacetyl-4-methylaniline which is crystallised from heptane, mp: 113-114° C.

Aufarbeitung

  1. washwashed with aqu
  2. customThe organic phase is dried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-a3456b5d6a45462da116fb640b9a79d2
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07906677B2

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